"Stibosan" (Von Heyden "471") in Private Practice

P p European female. H. M. = Hindu male. H. F. Hindu female. P = Palpable but not protruding below costal margin. I decided to try this compound on private patients so asked Dr. Napier for a quantity of it; he very kindly supplied me with a sufficient quantity to treat three patients. Later on I obtained the drug direct from the firm of von Heyden; it is now available from their agents in India,? Messrs. Allen & Hanburys. With my former experience with other antimony compounds I can say that " 471 " is much better, perhaps the best, of all antimony compounds that are now available in the market. I have put the results I obtained in my cases into tabular form for the convenience of readers; the points that struck me most with regard to the compound are:? (1) The rapidity with which it checks the fever. In my series of cases the average number of injections required to check the fever was three. (2) The short duration of the treatment; thus the patient is invalided for a short period only. (3) The rapid reduction in the size of the spleen. The spleen at first becomes thinned out, then diminishes in size, and from the fifth injection reduces very rapidly. (4) No untoward effects noted. In my cases no vomiting occurred after injection, not even after meals, and no pulmonary complications occurred. In all my cases the clinical diagnosis was confirmed by the aldehyde test which was strongly positive in every case. The cure* of the cases is judged by the fact that since the course of injections was finished none of them have had any return of fever. After the injections they rapidly gained weight.